HADH and malaria: falciparum is detected as HAD1 (PfHAD1) (PlasmoDB ID PF3D7_1033400), a sugar phosphatase member of the haloacid dehalogenase-like hydrolase (HAD) superfamily, which is detected as a negative regulator that acts upstream from the MEP pathway and could be further studied as a likely drug target against malaria (35).