MiR-155 knock-down leads to suppression of cell growth and colony formation as well as downregulation of epidermal growth factor receptor (EGFR), membrane-type 1 matrix metalloproteinase (MT1-MMP), and Kirsten rat sarcoma viral oncogene homolog (K-Ras) in pancreatic cancer (64). Here, KRAS is linked to familial pancreatic carcinoma.