In other hand, a recent study showed that the aqueous extract of the endocarp of fruits from C. ficifolia (pumpkin) decreased the body weight and inflammation in an obesity model induced by MSG in an obesity model mice (MSG-obese mice) through inhibiting the expression of tumor necrosis factor type alpha (TNF-α), interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), while it increased the protein levels of interferon-gamma (IFN-γ) and IL-10. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.