As known, D842V mutation (Exon 18 mutation) is the most frequent one among all the mutation types of PDGFRA in GIST, which renders PDGFRα protein stable and resistant to imatinib treatment.20-22 Unexpectedly, overexpression of PDGFRαD842V mutant in murine hepatocytes prevented liver regeneration after 2/3 PH, and inhibited DEN-induced hepatocarcinogenesis. Here, PDGFRA is linked to gastrointestinal stromal tumor.