AKT1 and Hepatic failure: However, compensatory increases of EGFR and MET expression then maintained later activation of Akt, which allowed for normal hepatocyte proliferation of KO mice at later stages.5 EGFR and Met expression are paramount during the process of liver regeneration and hepatocyte proliferation.23, 24 Combined systemic disruption of EGFR and Met signaling induced liver failure in normal mice.25 In fact, several previous studies have found that MET and EGFR could be activated within 30 to 60 minutes after PH.