Interestingly, PDGFRα might play an indispensable role at the early stage of embryonic growth and development, while after birth it was reduced to a non-major factor.2 However, activation of PDGFRα signaling has been verified in the development and metastasis of many types of cancers, including hepatocellular carcinoma (HCC). Here, PDGFRA is linked to hepatocellular carcinoma.