To be specific, the vascularization pattern and the major tumor size or tumor burden affects the treatment efficacy of TACE; ALBI grade is an assessment of liver function reserve and associated with HCC prognosis 26; AFP level is related to the differentiation of the cancer 27; and γ-GT level has been reported to be associated with tumor relapse and poor survival outcome 28. This evidence concerns the gene AFP and hepatocellular carcinoma.