Curcumin has been demonstrated to synergize with different agents such as genestin in breast cancer 54, with epigallocatechin-3-gallate in oral cancer 55, with tumor necrosis factor (TNF)- related apoptosis-inducing ligand (TRAIL) on LNCaP prostate cancer cells 56. This evidence concerns the gene TNFSF10 and lip and oral cavity carcinoma.