For instance, six subgroups (IDH, K27, G34, RTK I and II, and MES) in GBM 34, five molecular subtypes (Luminal A, Luminal B, Her2 overexpressing, basal, and normal-like) in breast cancers 35 and four subtypes in ESCA 36 can be noticed. This evidence concerns the gene ERBB2 and breast carcinoma.