For the new blood vessels to sprout and grow, hypoxia and the HIF pathway activation in the tumor cells are critical, since they regulate the expression of a collection of pro-angiogenic genes These includes the potent cytokines, vascular endothelial growth factor (VEGF)—an endothelial mitogen and pro-angiogenic factor, 39,49,50 angiopoietin-1, angiopoietin-2, platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF). This evidence concerns the gene FGF2 and neoplasm.