KDR and neoplasm: 190-195 It influences the balance of anti- and proangiogenic proteins, thereby creating a pathological environment. It is an inhibitor of tumor angiogenesis, progression, and metastasis through its association with certain receptors and proteins such as EGFRs, TGF-β, VEGF and VEGFR-2, and bFGF/FGF-2. 196