As an important survival mechanism of cells, UPR response plays an important role in the resistance of tumor cells to chemotherapy, which often causes chemoresistance due to the activation of IRE1α, leading to poor prognosis15.To determine whether oxaliplatin could activate IRE1α RNase activity, HCT116 and SW480 cells were treated with oxaliplatin of different concentrations. Here, ERN1 is linked to neoplasm.