CD274 and neoplasm: In the univariate analysis, PKM2, PD-L1, co-overexpression of both PKM2 and PD-L1 in tumor cells and immune cells, age, and depth of invasion showed significant correlation to the survival of lung AC patients (P<0.001, 0.047, 0.024, 0.019, 0.030, 0.017, 0.037 and 0.021 respectively; Table 3).