We searched HOTAIR from the Cancer Genome Atlas (TCGA) in cancers by online tools “GEPIA”, “UALCAN”and “Survexpress”, finding that expression of lncRNA HOTAIR was upregulated in colon cancer tissue (n=286) , especially the adenocarcinoma tissue (Fig. 1D, p < 0.01) and the paired normal colon tissue(n=41) by “UALCAN” database (http://ualcan.path.uab.edu) (Fig. 1A, p < 0.01) as well as upregulated higher in stage IV and stage III than that in stage I and stage II by “Gepia” database (http://gepia.cancer-pku.cn/) (Fig. 1B, p < 0.01). Here, HOTAIR is linked to malignant colon neoplasm.