PDK4 and hepatocellular carcinoma: Treatment of multiple HCC cell lines with the demethylating agent 5'-aza-2'-deoxycytidine (Aza) or histone deacetylase inhibitor trichostatin-A (TSA) showed an induction of PDK4 mRNA expression in Hep3B and HepG2 cells by Aza and in Hep3B, MH97H and MH97L cells by TSA 23.