PDK4 inhibition via RNA interference (RNAi)-mediated knockdown drove epithelial-mesenchymal transition (EMT) and promoted erlotinib resistance in EGFR mutant lung cancer cells 19, and siPDK4 in ovarian cancer cells promoted EMT and invasion but the effect was attenuated by PDK4 overexpression 20. The gene discussed is PDK4; the disease is lung carcinoma.