USP7 and cancer: Berberine has been reported to cause apoptosis by interaction of DAXX, disruption of MDM2-DAXX-HAUSP complex and degradation of MDM2 in acute lymphoblastic leukemia cells 12, while doxorubicin and VP-16 kill cancer cells through disruption of DAXX-MDM2-HAUSP complex, self-ubiquitination and degradation of MDM2, which leads to accumulation of p53 12, 25.