For example, a 70-year-old (25 points) synchronous BM patients from CRC with lymphatic metastasis (40 points), grade II (0 points), CEA positive (35 points) who undertake primary cancer surgery (0 points) and chemotherapy (0 points) has a total of 100 points, resulting the estimated 1-, 2-, 3-year CSS of 58.0%, 32.0% and 18.3%, compared to the total of 250 points with estimated 1-year CSS of less than 10% if the same patients don't receive neither surgery or chemotherapy. The gene discussed is CEACAM5; the disease is colorectal carcinoma.