HMGB1 and neoplasm: In terms of tumor progression, carrying TC or TT genotype in REV3L rs462779 had a lower risk of lymph node metastasis when compared with CC genotype, while carrying AG or AA genotype in HMGB1 rs1045411 or carrying GC or GG genotype in HMGB1 rs2249825 were significantly related to early T stage (T1 or T2).