In this study, we investigate the associations of HMGB1 (rs1045411, rs1412125, and rs2249825), REV3L (rs462779 and rs465646) and NFE2L2 (rs6706649, rs6721961, and rs35652124) with platinum-based chemotherapy prognosis in lung cancer patients. This evidence concerns the gene NFE2L2 and lung carcinoma.