INS and type 2 diabetes mellitus: In a randomized controlled clinical trial, of 4075 patients recruited to UKPDS, 1704 overweight patients with newly diagnosed T2DM (with baseline fasting blood glucose 110–270 mg/dL) were assigned to either conventional treatment with diet alone (n = 411), intensive control with metformin (n = 342) or intensive control with a sulfonylurea or insulin (n = 951).