Twelve DEGs (Myct1, Gm21860, Ninj2, Fam183b, Lars2, Alkbh1, Fgf5, Frmd7, Tm6sf2, Wnt6, Batf3, and Clca1) were found to be regulated inversely among the overlap genes, which may be possible targets of RPA to disrupt the cocaine addiction process (Fig. 5e). Here, RPA1 is linked to cocaine dependence.