The deficiency of TNFAIP3 in MSCs can induce immune thrombocytopenia and influence megakaryocytic differentiation through terminating the NF-κB pathway that suggests TNFAIP3 play a critical role in the process of MSCs alleviate s autoimmune disease [48]. This evidence concerns the gene TNFAIP3 and autoimmune thrombocytopenic purpura.