RPA1 and malignant colon neoplasm: Far-upstream element (FUSE)-binding protein 2 (FBP2) belongs to single-stranded DNA-binding protein family; it usually acts in regulating transcription and post-transcription and has been widely learned in liver tumors [27, 28] Kajiwara et al. demonstrated that in colon cancer tissues c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants were activated [29], which was also proved to induce invasion and migration of non-small cell lung cancer cells [30].