Previous studies have shown that the expression of SGLT2/SLC5A2 is increased in renal PTE cells from human subjects with T2DM.29, 30 By contrast, our immunohistochemical study showed no apparent differences in SGLT2/SLC5A2 expression in CPE and ependymal cells between subjects with and without DM (Fig. 3). This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.