CTLA-4+ Tregs also regulate neoplastic inflammatory infiltration by CD4+ T cells through interaction of CTLA-4 with CD80, which leads to a reduction in the number of CD4+ tumor-infiltrating T cells, preventing CTLA-4 from interacting with CD80 in an animal model of tumor infiltration by CD4+ lymphocytes [205]. This evidence concerns the gene CD4 and neoplasm.