CD8A and cancer: MDSC accumulation has been found to decrease the level of RIPK3, which enhanced oncogenic potential via the promotion of MDSC accumulation and increased immunosuppressive activity resulting from NF-κB upregulation, which regulated COX2 transcription and inhibited prostaglandin E2 (PGE2) release, thereby stimulating cancer cell proliferation while negatively influencing CD8+ T cells [100].