In our previously published studies, the interleukin 10 receptor alpha subunit (IL10RA), IL-10 and phosphorylated STAT3 showed a statistically significant positive correlation with the cell proliferation antigen Ki67 in CRC [33], which seems to confirm the importance of Janus kinase and signal transducer and activation of transcription (JAK-STAT) signaling in the pathogenesis of some tumors (Fig. 1A). The gene discussed is IL10RA; the disease is colorectal carcinoma.