Promotion of immunosuppression in HCC may also occur through the bioactivity of fibroblasts present in the tumor tissue, which through IL-6 induce activation of STAT3 in neutrophils, which simultaneously results in a positive co-expression of PD-L1 ligand within these cells and, by doing so, may reduce effector T cell activity against tumors [199]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.