Overexpression of NOR1 observed in HCC has been associated with an unfavorable prognosis, which is most likely due to acceleration of the immunosuppressive activity of NOR1+ TAMs by upregulation of arginase 1 (Arg1) expression and preferred polarization of macrophages towards the M2 subpopulation [54]. Here, ARG1 is linked to hepatocellular carcinoma.