Moreover, we detected a significant positive correlation of uPAR with histone H3 tri methyl K4 (H3K4me3, P = 0.041, Rho = 0.134) and a significant negative correlation with pN (P = 0.017, Rho = − 0.156), p16 (P = 0.05, Rho = − 0.13) and galectin-3 (P = 0.002, Rho = − 0.202) in 250 cervical cancer tissues (Table 1). The gene discussed is PLAUR; the disease is cervical cancer.