AKT1 and cancer: It is likely that the affinity of FPRK2 for lipoxin A4 and/or annexin A1 influences the activation of serine/threonine kinase, specifically the PI3K-Akt/PKB (protein kinase B) or MEK/ERK (mitogen-activated protein kinase) signaling pathways, as is the case for cancer cells characterized by increased proliferation, reduced apoptosis, and increased survival [16].