IL-8 is suggested to play a multifactorial role in the angiogenesis, tumour growth, metastasis and chemoresistance of tumours in vivo.35 IL-8 helps to recruit myeloid-derived suppressor cells, which inhibit T-cell proliferation and activation, into the tumour microenvironment in xenograft models.36 IL-8 was suggested as a potential prognostic marker in CRC.8 In this study, high IL-8 was also independently associated with poor survival. The gene discussed is CXCL8; the disease is neoplasm.