Chen et al. reported that a high NLR correlated with a distinct cytokine profile in metastatic CRC.26 In this study, the correlation between the NLR and cytokines was weak (IL-1β: ρ = 0.10, IL-6: ρ = 0.17 and VEGF-A: ρ = 0.10). The gene discussed is VEGFA; the disease is colorectal carcinoma.