For instance, Ets1 induces ZEB1 transcription in BRCA by binding to 5′-GGAT-3′ in the ZEB1 promoter; MEF2 activates ZEB1 transcription in colorectal cancer by binding to sequences rich in A/T, such as 5′-TAAATTTAT-3′, 5′-ATAATTTTAA-3′ and 5′-TTAATTTATA-3′ within the ZEB1 promoter; ISL1 induces ZEB1 transcription in gastric cancer by binding to TAAT in the ZEB1 promoter; Notch3 activates ZEB1 transcription by binding to the ZEB1 promoter, possibly through the Notch family-related 5′-RTGGGAA-3′ response element. This evidence concerns the gene ISL1 and colorectal cancer.