TWIST1 and familial pancreatic carcinoma: ZEB1 is aberrantly expressed in human BRCA and promotes BRCA metastasis.33,34 It has been identified as the key transcription factor for cell plasticity, local invasion and distant metastasis in mouse pancreatic cancer,35 since depletion of Snai1 or Twist1 in this model is unable to affect metastatic processes.