Compared with adjacent normal breast tissues, SLFN5 protein levels were significantly decreased in primary unmetastasised BRCA tumour tissues of each subtype (Un-met) and further decreased in local primary BRCA samples with distant metastasis (Distant-met) compared with Un-met (Fig. 1b, luminal A and triple negative; Supplementary Fig. S2, luminal B and HER2+). The gene discussed is ERBB2; the disease is neoplasm.