Myc transcriptionally regulated DC-SIGN expression on acinar cells and induced acinar-to-DC transition, which promoted type-1 T-helper (Th1) and T-helper 17 (Th17) cell differentiation, inhibited regulatory T cell (Treg) and type-2 T-helper (Th2) cell differentiation, and subsequently induced a local pro-inflammatory response in pancreatic tissues during AP. This evidence concerns the gene CD209 and alkaline phosphatase measurement.