In the present study, we aimed to pursue this question by testing the hypothesis that improvement in FMD in patients with chronic diseases whose pathophysiology involves oxidant stress and inflammation following initiation of anti-atherosclerotic liquid (AAL), anti-inflammatory capsules (AIC) and anti-oxidant liquid (AOL) therapies is directly linked to the relative reduction of inflammatory, oxidative stress and endothelial dysfunction markers, especially pentraxin 3 (PTX3), MDA and asymmetric dimethylarginine (ADMA). The gene discussed is PTX3; the disease is endothelial dysfunction.