Further, despite similar hepatic steatosis (cholesterol and triglyceride levels) and liver morphology between obese IFNAR−/− and WT counterparts (Supplementary Fig. 10a, b), obese IFNAR−/− mice had attenuated hepatocellular injury as measured by systemic alanine transaminase (ALT) levels (Fig. 4j; Supplementary Fig. 10c). This evidence concerns the gene IFNAR1 and fatty liver disease.