SOX2 and cancer: Our current results together with a previous study from our group demonstrating that MKP1 overexpression reduces tumorigenic properties and induces differentiation of GSCs whilst its levels are regulated by HDAC inhibitors24, and with another study describing a relationship between HDAC6 activity and SOX2 expression specifically in cancer stem cells33, postulate these genes and their underlying pathways as potential mediators of JOC1 activity.