Our current results together with a previous study from our group demonstrating that MKP1 overexpression reduces tumorigenic properties and induces differentiation of GSCs whilst its levels are regulated by HDAC inhibitors24, and with another study describing a relationship between HDAC6 activity and SOX2 expression specifically in cancer stem cells33, postulate these genes and their underlying pathways as potential mediators of JOC1 activity. This evidence concerns the gene HDAC9 and cancer.