In line with the tumor growth data, XEN445 therapy significantly decreased the number of Ki67-positive cells in xenograft tumors (150 ± 18/1000 tumor cells, n = 3, p < 0.001) when compared to vehicle-treated tumors (423 ± 27/1000 tumor cells, n = 3) (Fig. 6B). Here, MKI67 is linked to neoplasm.