We confirmed established pathogenesis in ICM and DCM including changes in many ECM proteins, a well-established feature of cardiac remodelling41, and in ICM changes in von Willebrand factor and serotonin indicating platelet activation, along with components of the blood coagulation cascade, highlighting the atherothrombotic pathogenesis of ICM. The gene discussed is VWF; the disease is familial dilated cardiomyopathy.