SAA1 and familial dilated cardiomyopathy: We report novel changes in ICM and DCM myocardium, including serum amyloid A1 protein, FMN, purines and pyrimidines, and novel gender-specific perturbations in histidine, acylcarnitines, ornithine, microbiome-derived atherogenic factor TMAO, and nitric oxide metabolites, permitting a better understanding of divergent HF pathogenesis between males and females.