Pathology in human malaria caused by P. falciparum is mainly attributed to the ability of maturing parasite iRBCs to express adhesive variant proteins collectively called erythrocyte membrane protein-1 at their surface and cytoadhere to endothelial receptors, notoriously the intercellular adhesion molecule (ICAM-1), in the microvasculature of different organs10. This evidence concerns the gene ICAM1 and malaria.