CARM1 asymmetrically di-methylates promoter histones H3R17 and H3R26, and triggers transcriptional activation of cell cycle regulatory and transcriptional factor genes, such as Cyclin E1 (CCNE1) [19], E2F1 [18] and CDKN1A [24] etc. However, to our knowledge, there are no previous reports probing the potential transcriptional targets of CARM1 in NSCLC. The gene discussed is CCNE1; the disease is non-small cell lung carcinoma.