TP53 and infection: Of all N-terminal peptide ratios altered during infection, those that significantly differed between wild-type versus mock infection were considered generally “infection dependent,” or those between wild-type versus ΔescN infection were considered specifically “T3S dependent.” These changes encompassed a network of 191 proteins across the human cellular and mitochondrial proteomes (Fig. 3), such as decreased initiator methionine (Met1) removal in the cell death-inducing p53 target protein during wild-type infection compared with uninfected cells.