In this light, a recent report regarding Snail-mediated suppression of fructose-1,6-bisphosphatase (FBP1) in triple-negative breast cancer is of special interest because loss of FBP1 suppresses endergonic gluconeogenesis from F1,6BP to F6P that is the reverse enzymatic reaction of PFK-1 (Dong et al, 2013). Here, PFKM is linked to triple-negative breast carcinoma.