We found that (1) ACC2 and Snail are inversely correlated in breast cancer tissue, (2) ACC2 and Snail transcript abundance were closely related to p53 status in clinical samples, and (3) ACC2 was down-regulated in triple-negative breast cancer and ERBB2-amplified subtypes (Fig S2), suggesting that Snail and ACC2 are specifically associated with breast cancer subtypes and p53 status. Here, ACACB is linked to breast cancer.