CD8A and squamous cell lung carcinoma: An increase in IFN-γ is often observed in CD8+ T cells after cancer immunotherapy, but the serum IFN-γ signature had no correlation with the OS of patients with squamous cell lung carcinoma.42 Moreover, elevated expression of serum IFN-γ was detected in the early post-treatment stage of immunotherapy, but no significant difference was noted at the late post-treatment stage (days 50–120), similar to our sampling time (post two cycles).43 44 Meanwhile, chemotherapy has been proven to attenuate the expression of proinflammatory cytokines.45