Other severe adverse events included elevated alanine aminotransferase (1 patient; 3%, grade 3), elevated aspartate aminotransferase (1 patient; 3%, grade 4), elevated lipase (1 patient; 3%, grade 3), hyponatremia (1 patient; 3%, grade 3), and hypertension (2 patients; 6%, grade 3). This evidence concerns the gene GPT and Hyponatremia.