TCF21 and esophageal squamous cell carcinoma: These SNPs are rs12190287 of TCF21 and rs10046 of CYP19A1. In our study, the genetic variant rs12190287 has been evaluated concerning ESCC and it was observed that the variant under study was associated with the higher risk of ESCC within the population of Jammu and Kashmir with OR 1.412 (1.09–1.8, at 95% CI, p = 0.008).