CYP19A1 and esophageal squamous cell carcinoma: The genetic variant in CYP19A1 (Cytochrome P450 family 19 sub-familyA1) rs10046 (C > T) has been associated with a higher risk of ESCC with OR 1.584 (1.21–2.072, at 95% CI, p = 0.007) as shown in Table 1.