More recently, in a population of 112 patients presenting with septic shock and mild-to-moderate AKI, we showed that, with an AUROC of 0.83 [0.75–0.90], urine [TIMP-2]*[IGFBP7] could be used to identify the subgroup of patients likely to display progression to severe AKI over the next 24 h [18]. Here, TIMP2 is linked to acute kidney injury.