CD8A and neoplasm: As TRM cells and CD8+ TILs have a common core residency gene program, we performed GSEA analysis using genes that are upregulated in tumor-infiltrating monocytes which comprising tumor-associated macrophages, T lymphocytes, and antigen-presenting cells and NK cells [37], and we found a significant enrichment in upregulated genes of CD8+dT cells (Fig. 3a).