We found that hypertension incidence was 7.6 (95% CI:6.5–8.7) per 100 PYs, and higher incidence was significantly associated with specific traditional (high BMI), and HIV-related risk factors (higher recent VL, lower recent CD4+/CD8+ ratio, lack of exposure of TDF or zidovudine). This evidence concerns the gene CD8A and Hypertension.