In this context, it has been shown that women that are heterozygous for certain genotypic polymorphisms of ESR2 present increased risk of HTN, especially those who use oral contraceptives [167], suggesting that specific single-nucleotide polymorphisms in ESR2 may transform the interaction of E2 with ERβ to a harmful axis regarding BP instead of a protective one. Here, ESR2 is linked to hypertensive disorder.