It was further shown that the activation of ERβ with a selective agonist in the paraventricular nucleus and rostroventrolateral medulla of OVX rats attenuates the sympathetic nerve activity reducing BP in aldosterone-induced HTN [35], suggesting that a potential decrease in ERβ levels or function with aging could contribute to SNS-mediated HTN in women. The gene discussed is ESR2; the disease is hypertensive disorder.