In the subgroup analysis by AF exposure assessment method, the pooled estimate revealed that there was a significant association between AF-albumin adduct and liver cirrhosis [4.89 (95% CI: 3.77–6.35, p = 0.000; I2 = 88.8%, p = 0.000)], as well as between 249ser TP53 mutation and liver cirrhosis [4.30 (95% CI: 2.55–7.26, p = 0.000; I2 = 0.00%, p = 0.863)] though no statistically significant association was observed between groundnut consumption and liver cirrhosis [1.15 (95% CI: 0.76–1.72, p = 0.51; I2 = 82.4%, p = 0.017)]. Here, TP53 is linked to cirrhosis of liver.