XPO1 and cancer: Interestingly, several XPO1 binding partners and/or adaptor proteins involved in nuclear export, namely RAN, HuR, eIF4E, LRPPRC, and NXF3, are also frequently overexpressed in human cancers and correlate with poor prognosis [24, 43–47], pointing to the aberrations of nuclear export machinery as a major hallmark of tumorigenesis.