BRAF and melanoma: Median OS was 7.5 months for concomitant CTLA-4-inhibitors, 17.8 months for concomitant BRAF-inhibitors and 20.4 months for concomitant anti-PD-1 treatment in a retrospective study of 108 melanoma patients receiving SRT for brain metastases (notably, 40% of patients received an additional WBRT) [22].