CD8A and neoplasm: It has been hypothesized that SRT has the propensity to synergize with IT through five factors: 1) inducing immunogenic cell death by generating antigens 2) promoting antigen presentation on MHC I molecules enhancing the tumor cell killing through CD8 cytotoxic T-cells, 3) increasing blood-brain-barrier-permeability, 4) inducing chemokines that help overcome T-cell exclusion from the metastases and 5) through the rare abscopal effect [26–28].