(4) CT-based DP model may reach the predictive level of the radiomics model in predicting the KRAS mutation status of CRC patients, while the DL can simplify the multi-step pipeline of the conventional radiomics method.However, there are still several limitations in the DL research field, including the insufficient number of patients, and further studies should be performed to optimize and verify its utility. Here, KRAS is linked to colorectal carcinoma.