AFP and neoplasm: Supplementary Table 2 collects the variable values in t1.The independent factors associated with OS at t0 were tumor size < 36.5 mm (cut-off estimated by AUROC) 30 vs 22 months HR 0.72 (95% CI 0.53–0.98, p = 0.039), basal AFP < 100 ng/mL (arbitrary value) 29 vs 18 months HR 0.67 (95% CI 0.47–0.96, p = 0.029) and basal alkaline phosphatase < 108 IU/L (median value) 32 vs 24 months HR 0.64 (95% CI 0.47–0.88, p = 0.005).