Gupta and colleagues reported that upregulation of HOTAIR in breast cancer patients is associated with higher mortality risk through PRC2-dependent silencing of proliferation and metastasis inhibitors.67 Additional studies have revealed its implication in various types of cancers, such as glioblastoma,68 castration-resistant prostate cancer,69 gastrointestinal tumors,70 and pancreatic cancer.71 Here, HOTAIR is linked to cancer.