A major noncoding risk allele for prostate cancer (PCa) susceptibility and aggressiveness, rs11672691, was found to reside within an enhancer element, located in intron 2 of the lncRNA PCAT19 locus, regulating the expression of the PCa-associated genes PCAT19 and CEACAM21. 37,38 The variant is characterized by stronger binding affinity for the TF HOXA2, which leads to the transcriptional activation of the aforementioned genes, resulting in increased proliferation and metastasis.37 Here, CEACAM21 is linked to posterior cortical atrophy.