Upon pro-inflammatory stimulation, LNC13 is degraded, allowing the expression of IL18RAP. However, in biopsies of intestinal tissue from CeD patients, LNC13 expression is significantly reduced and is associated with the rs917997 variant characterized by inefficient binding of hnRNPD, leading to impaired transcriptional repression of IL18RAP and continuous pro-inflammatory gene expression.65 This evidence concerns the gene HNRNPD and cranioectodermal dysplasia.