Finally, we identify two putative receptors targets for extracellular S100B (Receptor for Advanced Glycation End products (RAGE), RPTPσ) harboring consensus S100B binding motifs that may contribute to the extracellular S100B functions in both adipocyte innervation [15] and inflammation associated with obesity [31,32]. This evidence concerns the gene AGER and obesity due to melanocortin 4 receptor deficiency.