Indeed, the treatment (1) hampered the formation of tumour spheres, decreasing the levels of Sox-2 and sustaining GFAP levels (Figure 2); (2) reduced the number of viable GSCs (Figure 3); and (3) inhibited GSC migration and invasion (Figure 4), enhancing the functional effect of the unconjugated Gint4.T aptamer [32]. Here, SOX2 is linked to neoplasm.