SIRT6 and cardiac hypertrophy: In addition, SIRT2 and SIRT6 have emerged as prominent cardioprotective SIRTs [72,73], as deficiency of SIRT2 intensified cardiac hypertrophy in aged mice and mice stressed with angiotensin II [73], while a loss of SIRT6 in mice resulted in the development of cardiac hypertrophy and HF [74].