Moreover, SIRT1 inhibits effects of oxidative stress in T2D mice [45], promotes glucose-stimulated insulin secretion from pancreatic β-cells [46,47], and protects against insulin resistance in peripheral tissues [48], whilst SIRT1 overexpression promotes fatty acid oxidation and inhibits lipogenesis, protecting the liver from steatosis. This evidence concerns the gene INS and type 2 diabetes mellitus.